Chimeric Protein Designed by Genome-Scale Immunoinformatics Enhances Serodiagnosis of Bovine Neosporosis
نویسندگان
چکیده
منابع مشابه
Construction of chimeric protein 3M2e.FliC and its immunoinformatics analyses and expression in Bacillus subtilis
Introduction: Influenza A virus causes unpredictable epidemics and pandemics by creating antigenic variations. With the appearance of each new strain, rapid emergency countermeasures are taken against this new strain. Hence, designing an applicable and cross protective strategy to counter this virus is of great importance. To achieve this, choosing conserved antigenic regions in influenza virus...
متن کاملDiagnosis of bovine neosporosis.
The protozoan parasite Neospora caninum is a major cause of abortion in cattle. The diagnosis of neosporosis-associated mortality and abortion in cattle is difficult. In the present paper we review histologic, serologic, immunohistochemical, and molecular methods for dignosis of bovine neosporosis. Although not a routine method of diagnosis, methods to isolate viable N. caninum from bovine tiss...
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Reagent production: selecting the strain, preparing the antigen and controlling quality The choice of the strain to use is an extremely critical point. The use of the B103 strain, the reference strain used by Regalla et al. in 1999 to develop the IBT method, is highly recommended and should be used to ensure consistent results among laboratories. The antigen is then prepared from a culture grow...
متن کاملDesigning a Construct of Chimeric Multi-Epitopes Protein for Contraceptive Vaccine in Mice: An Immunoinformatics and In Silico Study
Background: Contraceptive vaccines (CVs) can be used as a valuable and alternative method for the prevention of gestation in humans and animals. These vaccines can have several targets, such as superficial sperm proteins. Vaccines based on sperm antigens are quite efficacious to create a contraceptive effect. However, multi-epitope vaccines are more effective in stimulating the immune system an...
متن کاملBovine Neosporosis: From Research to Clinic
Bovine neosporosis is a main cause of abortion worldwide. In dairy cattle, the economic burden of neosporosis-associated abortion is so great that it might results in closure of a farm. However, not all infected cows abort and it is not yet understood why this occurs. Humoral immune responses are not protective against N. caninum but seropositivity and antibody level can be good markers for a d...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2020
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.01343-19